【Original Contribution】 Marked Impairment of Human Erythrocyte Filterability Caused by Oxidant Stress with AAPH Precedes Oxidative Hemolysis
نویسندگان
چکیده
منابع مشابه
Verapamil prevents impairment in filterability of human erythrocytes exposed to oxidative stress.
Effects of oxidative stress on intact human erythrocytes were investigated using tert-butyl hydroperoxide (tBHP). Exposure of erythrocytes to tBHP caused a marked decrease in filterability in a time-dependent manner. Erythrocytes exposed to tBHP also show an increase in mean corpuscular volume and a remarkable formation of methemoglobin (met-Hb) without any appearance of hemichromes that form H...
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The RBC from mice of certain inbred strains hemolyzed under oxidative stress (2.0 mmol/L hydrogen peroxide), whereas red cells from mice of other strains did not. In the experimental system human erythrocytes did not hemolyze. The rate of formation of malonyldialdehyde (a fatty acid oxidative breakdown product) was fourfold higher in hemolytic v nonhemolytic red cells. There was insufficient va...
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Oxidative stress is seen in various metabolic disorders for unknown reasons. Oxidative stress is defined as an imbalance between pro-oxidant and antioxidant status in favor of the former. This study investigated whether oxidative stress exists in phenylketonuria (PKU) using the BTBR-Pah animal model for PKU. Animals (14–24 weeks old) were sacrificed and brain and red blood cells (RBCs) were obt...
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Coenzyme Q (CoQ10) is a component of the mitochondrial electron transport chain and also a constituent of various cellular membranes. It acts as an important in vivo antioxidant, but is also a primary source of O2 /H2O2 generation in cells. CoQ has been widely advocated to be a beneficial dietary adjuvant. However, it remains controversial whether oral administration of CoQ can significantly en...
متن کاملHEARING IMPAIRMENT CAUSED BY WAR
120 cases of Iranian soldiers complaining of hearing loss, were studied over a period of three years at the Ghaem Medical Center in Mashad,Iran. There was adequate information in III cases that their engagement in different types of explosions had caused their hearing impairment. The following aspects were evaluated: 1- Categorization of their hearing impairment. 2- The otoscopic findings...
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ژورنال
عنوان ژورنال: MEMBRANE
سال: 2014
ISSN: 0385-1036,1884-6440
DOI: 10.5360/membrane.39.48